Since the work of Dr Zamboni came to light in 2009 there have been many exciting developments and plans are in place for pilot studies to look at the role of dental clenching in the development of CCSVI. Here are the highlights that suggest we are getting very close to serious break throughs in the causes of MS and other neurological illnesses.
- CCSVI is clearly not the cause of MS but is a complication related to it the cause.
-the histology or microscopic evidence in blocked veins suggests that the changes are very similar to the blocked veins in Central Venous Stenosis related to altered pressure dynamics from long term kidney dialysis.
- these changes include an increase in fibrosis, smooth muscle proteins and a shift from collagen type I to collagen type III. (connective tissue that looks like scar tissue). These changes would suggest that an abnormal pressure pattern may contribute to the stenosis.
-Lyme disease sufferers who have neurological symptoms also have been found to have CCSVI. The appearance, behaviour, complexity and inflammatory influence of these bacteria are similar to the bacteria found in the gums of patients with periodontal disease. Bacterial infection may be centrally connected or may be a peripheral contributor to CCSVI. Either way it is interesting that a similar germ may be connected through the dental sources.
-Sleep disturbance and jaw clenching are found to be a large factor in MS. The differences between vascular blood flow at night versus day-time (ie Internal Jugular vs. Vertebral veins) could connect the timing of jaw clenching to triggers leading to CCSVI.